​***************TEAR STAINING EXPLAINED**************

***************TEAR STAINING EXPLAINED**************

If your dog suffer from tear stains you’ve probably often wondered what causes them?

You probably want to know how to remove tear stains.

When it comes to dogs' tear stains, most of the products available address bleaching and/or removing the tear stain but not eliminating the reason for the tear stains. Some vets like to say tear stains are natural in certain dogs and many vets even say there is no known explanation.Perhaps that’s because there is no convenient explanation for what causes tear stains.There is a scientific explanation for what causes tear stains and this article is all about science.
If you’ve done any research about tear stains on dogs you might have heard about Epiphora: excessive tear production.

If you’ve dug deeper into tear stains you might have heard about porphyrins.

The red/rusty stains on your dog are tear stains caused by porphyrins. Porphyrins are commonly called waste products from red blood cells containing iron.

Porphyrins are created during the normal cycle of biosynthesis of hemoglobin to create energy. They are created in humans, too. Every day, red blood cells are naturally broken down in the body during Krebs cycle which produces CO2 and generates energy molecules.

This is known as heme biosynthesis. During this cyclic process, a chemical substance known as porphyrin is left in the body and excreted. Excreted thru the liver, it becomes part of bile. It can be part of urine or in this case, tear stains.

The cycle: Glycine & Succinyl CoA is needed for heme biosynthesis to begin.

Aminolevulinic acid - ALA - is the catalyst. Pyriodxal phosphate (B6) and ALAS1 (Aminolevulinic Acid Synthase) are needed to convert Glycine and succinyl CoA to ALA. Condensation with Succinyl CoA takes place while the amino base glycine is in schiff base linkage to the aldehyde of Pyriodxal phosphate (B6) and it converts Succinyl CoA to ALA Heme itself, then acts as a feedback inhibitor to ALA and ALAS1 ALAS1 is one of the co-factors needed for the liver's housekeeping, removal of overall accumulation of toxic metabolics.

Medically speaking, Porphyrias; which would be indicated by excess Porphyrins – red/rusty tear stains, is the condition which results when there are specific enzyme deficiencies in the heme synthesising pathway.This is when the co-factors are not present to stopthe cyclic process.

In simple terms, remove excess toxins that are accumulated in and removed by the liver and you will remove the co-factor that tear production depends upon.
You'll also be doing your dog's liver a favour!

The most common triggers of excess of Porphyria are Sulfonomides. Sulfonomides are FDA approved bacteriostatic chemicals.Sulfonamides are frequently used in pigs, cattle and chicken for the treatment and prevention of bacterial diseases. Sulfonamides (sulfa drugs) Sulfonamides are produced by chemical synthesis. They have bacteriostatic activity against a broad spectrum of pathogens. They interfere with RNA and DNA, which are necessary for cell growth and replication.

BRIGHTWORKS contains a UNIQUE blend of herbs and an Enzyme that improves liver function SUPPRESSES THE FORMATION OF PORPHYRINS-therefore resulting in NO MORE TEAR STAINS!!!!!!!!!!!